A misaligned firing order on the Chevy 350 is going to cause your engine a whole lot of trouble. It will be small at first, but as you continue to use it, it will get worse and worse. Some people mention that they can get their 350 to turn over but they can’t get it to stay running, and that’s a clear sign of misaligned firing order. If you notice this happening to your engine, take it to a mechanic immediately.